The west-Central Africa Enhancing Malaria Epidemiology Research through Genomics and Translational Systems biology (EMERGENTS) ICEMR program leverages successful, well-established collaborations, unique research and training infrastructures, and an extensive Sub-Saharan Africa (SSA) research network to address emerging and challenging issues in malaria transmission in the region. EMERGENTS ICEMR is built on a proven research platform and consortium, including the of World Bank, the Wellcome trust, the African Academy of Sciences, research centers of excellence in Nigeria and Cameroon funded by the NIH and the Centers for Disease Control and Prevention. By leveraging existing infrastructure, the ICEMR team can launch directly into « advancing science », assuring implementation of rigorous and advanced approaches to tackling high-priority emerging and re-emerging issues in malaria that remain as significant impediments to achieving malaria elimination and eradication (MEE). The robust consortium of renown malaria research and program partners involved in this program assures the implementation of rigorous and advanced approaches to tackling high priority emerging and re-emerging issues negatively impacting progress toward the 2030 Sustainable Development Goals (SDGs) for malaria, namely reducing case incidence and related deaths by at least 90% against a 2015 baseline.